Virtual Reality for Psychophysiological Assessment

See how people actually respond

VR scenarios optimised and validated for impact, paired with synchronised biometric capture, time-locked to what the participant sees and does.

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Self-report only tells you half the story

Questionnaires and structured interviews still dominate the measurement of human response. They flatten rich, moment-to-moment reactions into static scores, and the real signal of how people actually behave and adapt gets lost.

The cost: drug trials where placebo masks treatment effect, diagnostic assessments blind to reactivity, hiring decisions made on what candidates say rather than how they perform.

“There is widespread disillusionment with traditional psychometric instruments that distill dynamic experiences into static scores, alongside the growing potential of ecologically valid assessments to model moment-to-moment psychological functioning.”

JAMA Psychiatry, 2025

Show something real, measure how the body responds

Two systems, one platform: a marker-proven VR content CMS and a clinical-grade biometric pipeline. Scenarios optimised and validated for impact by our in-house psychology and psychiatry team, delivered consistently to every participant, with the physiological response captured automatically.

6+ Physiological signals captured simultaneously
10+ Years of VR content platform experience

Where BioXR is used

One platform across clinical trials, diagnostics, talent assessment and academic research.

Pharma & Clinical Trials

Reproducible psychophysiological endpoints that cut noise from self-report and placebo response.

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Mental Health Diagnostics

Validated VR assessments that capture the moment-to-moment reactivity questionnaires miss.

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Workforce & Recruitment

Bespoke scenarios for aptitude, focus and stress-reactivity, with biometric data behind every result.

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Research & Academia

Ecologically valid experiments with synchronised multi-modal capture and population-level analytics.

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A market-proven platform for VR content

A clinical-grade content management system derived from a platform with over 10 years in commercial use. Author a scenario, deliver it to the headset, and BioXR handles versioning, deployment and provenance automatically.

Enterprise VR content platform

A mature CMS for authoring, deploying and version-controlling VR scenarios at scale, derived from a content platform with 10+ years in commercial use. Two scenario families.

  • 360° video. Naturalistic, high-fidelity environments for triggering emotional reactivity.
  • CGI environments. Interactive scenes for cognitive, attention and behavioural tasks.

In-house content production

Scenarios are optimised and validated for impact, not just customised. Over a decade of in-house experience across:

  • Filming & CGI production. Studio and on-location 360° capture, plus a CGI pipeline for bespoke interactive environments.
  • Psychology & psychiatry team. Content designed to elicit specific reactions, or calibrated for particular clinical and demographic populations.

Synchronised, clinical-grade biometric pipeline

While the participant is in the scenario, BioXR captures, cleans and time-locks six families of physiological signal to scenario events.

Heart Rate & HRV Cardiac reactivity and autonomic nervous system dynamics
Electrodermal Activity Skin conductance reflecting emotional arousal intensity
Respiration Breathing rate and pattern changes under stress
Eye Tracking & Pupillometry Where they look, how long, and how their pupils respond
Skin Temperature Peripheral temperature shifts indicating stress response
Movement & Head Tracking Spatial behaviour and physical orientation in the VR space

Every signal time-locked to scenario events

A growing library of validated scenarios

Our scenarios are validated and verified through peer-reviewed research, with the library continuing to grow through in-house development and external collaboration.

Emotional Exposure

Validated 360° video scenarios for emotional exposure and reactivity, peer-reviewed in controlled VR settings.

Eur Neuropsychopharmacol, 2024 →
Cognitive Assessment

A validated VR test for daily-life cognitive function, with sensitivity demonstrated in mood and psychosis spectrum disorders, bipolar disorder, ADHD comorbidity, treatment response and an English-language version.

J Psychiatr Res, 2022 →
Selected publications 8 papers
  1. Miskowiak KW, Jespersen AE, Kessing LV, et al. Cognition Assessment in Virtual Reality: Validity and feasibility of a novel virtual reality test for real-life cognitive functions in mood disorders and psychosis spectrum disorders. J Psychiatr Res. 2022;145:182–189. doi:10.1016/j.jpsychires.2021.12.002
  2. Jespersen AE, Obel Z, Lumbye A, Kessing LV, Miskowiak KW. Bipolar-ADHD comorbidity: screening for differences in neurocognition and virtual reality-based cognitive performance. Nord J Psychiatry. 2024;78(3):238–246. doi:10.1080/08039488.2024.2309496
  3. Jespersen AE, Lumbye A, Schandorff J, et al. Cognition Assessment in Virtual Reality (CAVIR): Associations with neuropsychological performance and activities of daily living in patients with mood or psychosis spectrum disorders. J Affect Disord. 2025;369:1053–1063. doi:10.1016/j.jad.2024.10.095
  4. Jespersen AE, Lindhardsen JM, Lumbye A, et al. Virtual reality-based cognitive screening in psychiatry: Investigating optimal cut-offs for cognitive impairment in bipolar disorder. Neurosci Appl. 2025;5:106880. doi:10.1016/j.nsa.2025.106880
  5. Lewandowski KE, Luo J, Kolstad J, et al. Cognition Assessment in Virtual Reality (CAVIR)-English Version: Validation of a Novel Virtual Reality Test for Daily Life Cognitive Functions in Patients With Affective Disorders. Acta Psychiatr Scand. 2026;153(5):544–552. doi:10.1111/acps.70077
  6. Jespersen AE, Montejo L, Damgaard V, et al. Readiness to change: Exploring clinical, cognitive and neural predictors of treatment efficacy following virtual reality-based cognitive remediation in mood and schizophrenia spectrum disorders. J Affect Disord. 2026;403:121482. doi:10.1016/j.jad.2026.121482
  7. Jespersen AE, Lumbye A, Vinberg M, et al. Virtual reality-based cognitive remediation versus virtual reality control in people with mood or psychosis spectrum disorders in Denmark: a single-centre, double-blind, randomised controlled trial. Lancet Digit Health. 2026:101002. doi:10.1016/j.landig.2026.101002
  8. Validation of a virtual reality paradigm for emotional exposure. Eur Neuropsychopharmacol. 2024. doi:10.1016/j.euroneuro.2024.11.006

Publish your tests on BioXR

Researchers with validated paradigms can license, publish and distribute their tests through BioXR. Joint development with our content and psychology teams brings new tests to the platform and broader reach to your work.

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What's in the platform

Authoring, running and analysing studies in one place. Encrypted and role-based.

Mature Content Platform

10+ year-proven CMS for authoring, versioning and deploying VR content across 360° video and CGI.

Session Explorer

Drill into individual sessions with synchronised VR and bio timelines side by side.

Population Analytics

Compare groups, cohorts, and treatment conditions with aggregated physiological metrics.

Scenario Comparison

See how different VR content drives distinct response patterns across your population.

Study Management

Organise participants, manage access, and maintain audit-ready records.

Data Export & API

Export processed signals for your own statistical pipelines, or integrate via our API.

VR SCENARIO BIO SENSORS BioXR Platform

Let's talk about what you're working on

Trial, clinic, talent assessment or research lab: get in touch and we'll show you what BioXR can do for your study.

info@bioxr.dk